Matheo graduated from New York University School of Medicine and went on to be resident and chief resident at Harbor-UCLA Medical Center. She joined the division of Adolescent and Young Adult (AYA) Medicine in 2005, having been on staff as a general pediatrician at UPMC/Children’s Hospital since 1992 while working as lead physician at Duquesne University Health Services. During her time with the division, she has served as program director for the adolescent medicine fellowship up until January of 2022. During her tenure the program went from a complement of three fellows to five.

Improving access to care has guided her career. She serves as the liaison for embedded model of Adolescent Medicine with Children’s Community Pediatrics, has headed the task for Transition to Adult Care and currently sits on the Telehealth Steering Committee. Access is part of inclusion for all and most recently she was appointed Vice Chair for Diversity, Equity & Inclusion for the Department of Pediatrics. During this time, she has successfully worked to recruit and mentor faculty and trainees from historically marginalized communities as well as facilitating programming to improve cultural competency the department of Pediatrics while working in collaboration with other DEI champions at UPMC/Children’s Hospital and across all UPMC